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The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma
Seiji Kishi1, Fumiaki Obata1, Hirokazu Miki2
1Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan.
Abstract:
Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.
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