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Assessment of Bone Fracture Healing Using Micro-Computed Tomography
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Quantification of voxel values in micro computed tomography using multiple porosity hydroxyapatite blocks.

Munetaka Naitoh1, Hirofumi Watanabe1, Ryosuke Kuwana1

  • 1Department of Oral and Maxillofacial Radiology, School of Dentistry, Aichi Gakuin University.

Okajimas Folia Anatomica Japonica
|August 14, 2018
PubMed
Summary

Microfocus X-ray computed tomography (micro-CT) can quantify bone density. This study demonstrates that micro-CT voxel values can be converted to hydroxyapatite (HA) densities using linear regression, enabling accurate bone assessments.

Keywords:
bone mineral densityhydroxyapatitemicro computed tomographyquantificationvoxel value

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Radiology

Background:

  • Microfocus X-ray computed tomography (micro-CT) is crucial for non-destructive analysis of bone and dental structures.
  • Micro-CT derived voxel values lack absolute quantification, necessitating calibration for precise material density assessment.

Purpose of the Study:

  • To establish a quantitative relationship between micro-CT voxel values and hydroxyapatite (HA) densities.
  • To validate the reproducibility of this quantitative method.

Main Methods:

  • Hydroxyapatite (HA) blocks with varying porosity and a soft tissue-equivalent block were scanned using micro-CT.
  • Voxel values were measured, and correlations with known HA densities were analyzed.
  • Linear regression analysis was performed to establish a conversion equation.

Main Results:

  • A strong linear correlation was observed between micro-CT voxel values and HA densities.
  • The derived regression equations showed high reproducibility between repeated measurements.
  • Binary image analysis of pixel ratios was also performed.

Conclusions:

  • Micro-CT voxel values can be reliably converted to absolute hydroxyapatite densities using linear regression.
  • This calibration method enhances the accuracy of micro-CT for quantitative bone and dental tissue analysis.