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Body Mass Index as a Prognostic Marker in Glioblastoma Multiforme: A Clinical Outcome
Mahadev Potharaju1, Balamurugan Mangaleswaran2, Anugraha Mathavan1
1Department of Radiation Oncology, Apollo Specialty Hospitals, Chennai, India.
International Journal of Radiation Oncology, Biology, Physics
|August 14, 2018
Summary
Higher body mass index (BMI) is linked to better survival outcomes in glioblastoma patients. Further research is needed to understand the mechanisms behind this association between BMI and glioblastoma survival.
Area of Science:
- Oncology
- Clinical Research
- Epidemiology
Background:
- Glioblastoma is an aggressive brain tumor with limited treatment options.
- The correlation between body mass index (BMI) and glioblastoma patient outcomes is not well-established.
- Understanding prognostic factors like BMI is crucial for improving patient care.
Purpose of the Study:
- To investigate the association between pretreatment body mass index (BMI) and overall survival (OS) in patients diagnosed with glioblastoma.
- To determine if BMI is a significant predictor of clinical outcome in glioblastoma.
Main Methods:
- Retrospective analysis of 392 histopathology-confirmed glioblastoma patients.
- BMI categorized as normal (18.5-24.9 kg/m²), overweight (25.0-29.9 kg/m²), and obese (≥30.0 kg/m²).
- Overall survival (OS) analyzed using univariate and multivariate Cox proportional hazards models, adjusting for clinical factors.
Main Results:
- Median OS was 13.5 months for normal BMI, 15.4 months for overweight, and 15.1 months for obese patients.
- Overweight and obese patients showed significantly better OS with hazard ratios of 0.70 and 0.66, respectively, after adjustment.
- No significant interactions were found for sex, diabetes, or hypertension.
Conclusions:
- Elevated body mass index (BMI) is associated with significantly better overall survival in glioblastoma patients.
- The underlying biological mechanisms driving this improved survival in patients with higher BMI require further investigation.
- BMI may represent a modifiable or observable factor influencing glioblastoma prognosis.
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