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Tunable Interfacial Properties in Silk Ionomer Microcapsules with Tailored Multilayer Interactions.

Ren Geryak1, Elizabeth Quigley1, Sunghan Kim1

  • 1School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Macromolecular Bioscience
|August 14, 2018
PubMed
Summary

Researchers developed novel silk ionomer microcapsules for controlled material transport. These biocompatible capsules exhibit pH-responsive properties, offering tunable stiffness and diffusion for advanced applications.

Keywords:
biomaterialslayer-by-layer assemblymicrocapsulesresponsive materialssilk fibrointunable transport

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Nanotechnology

Background:

  • Microencapsulation is key for controlled functional material transport in multiphase systems.
  • Silk ionomers, modified silk fibroin with charge groups, offer enhanced biocompatibility.
  • Previous limitations in silk ionomer grafting density hindered stable microcapsule fabrication.

Purpose of the Study:

  • To demonstrate the first microcapsules from minimally grafted silk ionomers.
  • To fabricate and characterize microcapsules from polyethylene-glycol-grafted silk ionomers.
  • To investigate the impact of assembly conditions on microcapsule properties.

Main Methods:

  • Preparation of silk ionomers with varying grafting densities.
  • Fabrication of microcapsules using silk ionomers and polyethylene-glycol-grafted silk ionomers.
  • Characterization of microcapsule pH-responsiveness (stiffness, diffusion).
  • Analysis of assembly conditions' effect on microcapsule morphology and transport.

Main Results:

  • Successfully fabricated stable microcapsules from minimally grafted silk ionomers.
  • Demonstrated pH-responsive behavior: tenfold decrease in stiffness and threefold change in diffusion coefficient from acidic to basic conditions.
  • Showed that assembly conditions significantly influence microcapsule properties, including roughness, stiffness, and pH-dependent transport.

Conclusions:

  • Minimally grafted silk ionomers enable stable, biocompatible microcapsule fabrication.
  • Silk ionomer microcapsules exhibit significant pH-responsiveness, tunable via grafting and assembly.
  • These findings pave the way for advanced controlled delivery systems using tailored biomaterials.