Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

68.3K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.3K
Factors Affecting Solubility04:01

Factors Affecting Solubility

37.2K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K
Solubility Equilibria03:07

Solubility Equilibria

57.5K
Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
57.5K
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

26.6K
Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
26.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Solubility03:00

Solubility

21.2K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
21.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oversimplified immunology is holding biomaterials back.

Nature reviews bioengineering·2026
Same author

Lipid nanoparticle composition directs systemic trafficking and tissue-specific T cell immunity after intramuscular injection.

Nature biomedical engineering·2026
Same author

Engineering age-adaptive mRNA lipid nanoparticle cancer vaccines via reprogramming systemic gene expression.

bioRxiv : the preprint server for biology·2026
Same author

PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy.

Neoplasia (New York, N.Y.)·2026
Same author

Taking Action on Concurrent Disorders: Calls for Action on Collaborative Research Priorities in Canada.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2026
Same author

Expertise-dependent mental representation in chess: evaluation and comparisons based on structural dimensional analysis-motoric.

Frontiers in psychology·2026

Related Experiment Video

Updated: Feb 6, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

15.2K

Soluble MHC class I complexes for targeted immunotherapy.

Anna Schappert1, Jonathan P Schneck2, Lauren Suarez3

  • 1Paul-Ehrlich-Institute, Division of Immunology, Langen, Germany; Medical Clinic 1, University Hospital/Goethe University of Frankfurt am Main, Germany.

Life Sciences
|August 14, 2018
PubMed
Summary
This summary is machine-generated.

Soluble Major Histocompatibility Complex (MHC) class I molecules are valuable tools in tumor immunotherapy for detecting T cells and enhancing anti-tumor responses. Their application in vaccination studies shows promise for monitoring and treatment strategies.

Keywords:
ImmunotherapyMHC-class IT cellsTumorVaccination

More Related Videos

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.8K
Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

22.2K

Related Experiment Videos

Last Updated: Feb 6, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

15.2K
Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.8K
Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

22.2K

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Major Histocompatibility Complex (MHC) molecules are crucial in immune responses.
  • MHC complexes have been utilized in tumor immunotherapy for over 20 years.
  • Their application spans both clinical and pre-clinical research settings.

Purpose of the Study:

  • To review the utilization of soluble MHC class I complexes in tumor vaccination.
  • To highlight diverse strategies and conflicting outcomes associated with their use.
  • To underscore the potential of soluble MHC class I in advancing cancer immunotherapy.

Main Methods:

  • Review of existing literature on soluble MHC class I in tumor immunotherapy.
  • Analysis of different strategies employing soluble MHC class I multimers, cell-bound forms, and artificial antigen-presenting cells (aAPCs).
  • Evaluation of studies focusing on tumor vaccination and anti-tumor T cell detection.

Main Results:

  • Soluble MHC class I complexes are effective in detecting anti-tumor T cells.
  • These complexes can be presented via various platforms, including soluble multimers, cells, and aAPCs.
  • Evidence suggests they can elicit effective anti-tumor immune responses.

Conclusions:

  • Soluble MHC class I molecules are versatile tools in tumor immunotherapy.
  • Their application in vaccination studies reveals varied results, necessitating further investigation.
  • These molecules hold significant potential for improving cancer monitoring and therapeutic strategies.