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Gene encoding T-cell-activating protein TAP maps to the Ly-6 locus
Summary
This study genetically analyzes T-cell-activating protein (TAP) and TAP-associated protein (TAPa). Findings show TAP and TAPa are distinct Ly-6 locus molecules with complex expression patterns.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Two murine T-cell membrane proteins, TAP and TAPa, were previously identified.
- Preliminary data suggested TAP's role in physiological T-cell activation.
Purpose of the Study:
- To perform a genetic analysis of TAP and TAPa.
- To investigate the relationship of TAP and TAPa to other Ly-6 locus antigens.
- To characterize the expression patterns of Ly-6 locus encoded molecules.
Main Methods:
- Genetic mapping of TAP and TAPa to the Ly-6 locus.
- Comparative analysis of tissue distribution, molecular structure, and functional properties.
- Examination of coexpression patterns and developmental regulation.
Main Results:
- TAP and TAPa were mapped to the Ly-6 locus.
- TAP is a novel Ly-6 antigen, distinct from previously described ones.
- TAPa is likely identical to the 34-11-3 antigen.
- TAP and TAPa show coexpression across examined cell types.
- A complex, developmentally regulated expression pattern for Ly-6 locus molecules was observed.
Conclusions:
- TAP and TAPa are distinct members of the Ly-6 locus.
- The Ly-6 locus encodes molecules with intricate and developmentally controlled expression.
- These findings contribute to understanding T-cell activation and immune system regulation.