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Related Experiment Video

Updated: Feb 6, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Reticulated Platelets: Changing Focus from Basics to Outcomes.

Bashar Hannawi¹, Yousef Hannawi², Neal S Kleiman¹

¹Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, United States.

Thrombosis and Haemostasis

|August 14, 2018

Summary

Reticulated platelets (RPs), the youngest platelets, indicate turnover and are elevated in cardiovascular disease. Higher RP levels may increase the risk of ischemic events and reduce anti-platelet drug effectiveness.

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Last Updated: Feb 6, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Published on: November 29, 2024

Microfluidics in Assessing Platelet Function

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Published on: November 8, 2024

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Area of Science:

Cardiovascular Medicine
Hematology
Thrombosis Research

Background:

Platelets are crucial in atherothrombosis.
Reticulated platelets (RPs) are young platelets reflecting platelet turnover.
Elevated RP levels are observed in coronary artery disease (CAD) and stroke patients.

Purpose of the Study:

To review the role of RPs in CAD.
To discuss RP implications in anti-platelet drug hypo-responsiveness.
To explore mechanisms linking RPs to ischemic events.

Main Methods:

Literature review of studies on RPs, atherothrombosis, and anti-platelet therapy.
Analysis of current evidence on RP function and clinical significance.
Synthesis of findings related to CAD and stroke.

Main Results:

Increased circulating RPs are linked to higher ischemic event risk (e.g., acute coronary syndrome, stroke).
RPs may contribute to thrombosis via mRNA translation.
Newly released RPs might evade anti-platelet drug effects.
RPs could serve as a marker of inflammation.

Conclusions:

RPs are significant in atherothrombosis pathophysiology.
RP levels may predict ischemic events in cardiovascular disease.
RPs are implicated in reduced responsiveness to anti-platelet medications.