Related Experiment Video
Updated: Feb 6, 2026

An Efficient Method to Obtain Dedifferentiated Fat Cells
Published on: July 15, 2016
Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicine
Martina Pesaresi1, Ruben Sebastian-Perez1, Maria Pia Cosma1,2,3
1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Spain.
Abstract:
Regenerative capacities vary enormously across the animal kingdom. In contrast to most cold-blooded vertebrates, mammals, including humans, have very limited regenerative capacity when it comes to repairing damaged or degenerating tissues. Here, we review the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation and reprogramming. We discuss the significance of cell fate and identity changes in the context of regenerative medicine, with a particular focus on strategies aiming at the promotion of the body's self-repairing mechanisms. We also introduce some of the most recent advances that have resulted in complete reprogramming of cell identity in vivo. Lastly, we discuss the main challenges that need to be addressed in the near future to develop in vivo reprogramming approaches with therapeutic potential.
Related Concept Videos
Forced Transdifferentiation
Artificial...
Nuclear Fusion
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Somatic to iPS Cell Reprogramming
Induced Pluripotent Stem Cells
Microorganisms in Medicine and Therapeutics
Introduction to Nuclear Reprogramming

