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Psychological burden of pediatric primary immunodeficiency

Binay Kayan Ocakoglu1, Neslihan Edeer Karaca2, Fevzi Tuna Ocakoglu1

  • 1Child Psychiatry Outpatient Clinic, Batman District State Hospital, Batman, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 14, 2018
PubMed

Insights

Children with primary immunodeficiency disorder (PID) and juvenile idiopathic arthritis (JIA) experience similar rates of psychopathology, which are higher than in healthy children. Disease factors impact mood disorders in PID patients.

Area of Science:

  • Pediatric Psychology
  • Immunology
  • Child Psychiatry

Background:

  • Chronic conditions like primary immunodeficiency disorder (PID) may elevate psychopathology risk.
  • Limited research exists on disease-specific factors influencing mental health in pediatric PID patients.
  • This study compares mental health in children with PID, juvenile idiopathic arthritis (JIA), and healthy controls.

Purpose of the Study:

  • To assess and compare the mental health status of children with PID undergoing i.v. immunoglobulin treatment, children with JIA, and healthy controls.
  • To investigate the association between disease-related factors and psychopathology in children with PID.

Main Methods:

  • Psychiatric evaluations were conducted on 44 children with PID, 32 with JIA, and 30 healthy controls.
  • Participants completed the Childhood Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders questionnaire.
  • Mothers of participants completed the Child Behavior Checklist; disease-related factors were identified.

Main Results:

  • The prevalence of mood disorders differed significantly across the three groups.
  • No significant difference in mood disorders or other psychopathologies was found between the PID and JIA groups.
  • Disease-related factors were associated with mood disorder frequency in PID patients.

Conclusions:

  • Children with PID and JIA exhibit higher rates of psychopathology compared to healthy controls.
  • The prevalence of psychopathology is comparable between pediatric PID and JIA populations.
  • Specific disease-related factors correlate with the occurrence of mood disorders in children with PID.
Abstract

Keywords:
childrenchronic diseasei.v. immunoglobulin treatmentprimary immunodeficiencypsychopathology

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