The Prognosis in Palliative care Study II (PiPS2): study protocol for a multi-centre, prospective, observational,
Anastasia K Kalpakidou1, Chris Todd2, Vaughan Keeley3
1Marie Curie Palliative Care Research Department, Division of Psychiatry, UCL, 6th Floor, Maple House, 149 Tottenham Court Road, London, W1T 7NF, UK.
BMC Palliative Care
|August 15, 2018
Summary
The Prognosis in Palliative care Scales (PiPS) models accurately predict survival for advanced cancer patients. This validation study confirms their feasibility and clinical utility in palliative care settings.
Area of Science:
- Palliative Care
- Oncology
- Biostatistics
Background:
- Accurate prognostication is crucial for end-of-life care quality.
- Prognosis in Palliative care Scales (PiPS) are validated prognostic models for survival.
- PiPS-A (no blood tests) and PiPS-B (with blood tests) predict survival in days, weeks, or months.
Purpose of the Study:
- To validate the Prognosis in Palliative care Scales (PiPS) models.
- To evaluate the accuracy of other prognostic tools in advanced cancer patients.
- To assess the clinical utility and acceptability of prognostic models.
Main Methods:
- A national, multi-centre, prospective, observational cohort study.
- Recruited 1778 patients with advanced, incurable cancer referred to palliative care.
- Compared PiPS-A and PiPS-B accuracy against clinicians' survival estimates and actual survival.
Main Results:
- The study successfully recruited over the target sample size, demonstrating feasibility.
- PiPS models were validated against actual patient survival and clinician estimates.
- Accuracy of other prognostic tools (PPI, PPS, PaP, FPN) was evaluated.
Conclusions:
- Recruitment of a large cohort for a prospective palliative care study is feasible.
- The validation of PiPS models supports their use in clinical practice.
- Qualitative sub-study assesses acceptability and barriers to clinical implementation.
Related Concept Videos
01:11Observational Studies
11.1K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
01:22Case Studies
13.6K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.6K
01:26Varicose Veins II: Diagnostic Studies and Interprofessional Care
224
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
224
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
462
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
462
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
320
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
320
01:28Imaging Studies I: Kidney, Ureter, and Bladder Studies
370
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
370