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Modifying the physicochemical properties of NSAIDs for nasal and pulmonary administration
1University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u 6, 6720 Szeged, Hungary.
Abstract:
This review focuses on nasal and pulmonary delivery of NSAIDs (non-steroidal anti-inflammatory drugs) for fast-onset analgesia, for the potential prevention of Alzheimer's disease (AD), as well as for an add-on treatment in cystic fibrosis (CF) and non-small cell lung cancer (NSCLC). I discuss how the physicochemical properties of NSAIDs can be modified with respect to the biological characteristics of the target site. Innovative technology and/or dosage forms can promote an effective therapy.
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