Plasma β-amyloid_1-42 reference values in cognitively normal subjects.

Area of Science:

• Biochemistry
• Neuroscience
• Clinical Diagnostics

Background:

• Plasma beta-amyloid 1-42 (Aβ_1-42) is a potential Alzheimer's disease biomarker.
• Clinical application is hindered by a lack of established reference values.
• This study aimed to determine Aβ_1-42 plasma concentrations in healthy individuals.

Purpose of the Study:

• To evaluate plasma Aβ_1-42 concentrations in cognitively normal subjects.
• To propose reference values for plasma Aβ_1-42 for clinical use.

Main Methods:

• Analyzed plasma samples from 245 subjects aged 19-89 years.
• Categorized participants into three age groups: young (≤34), adult (35-64), and old (>64).
• Utilized the Innogenetics Elisa kit for plasma Aβ_1-42 quantification.

Main Results:

• The mean plasma Aβ_1-42 concentration was 17.65 (5.71) pg/mL.
• A significant positive trend in Aβ_1-42 levels was observed across age groups (p < .0001).
• Established 90% reference interval for the cohort: 8.12 pg/mL (lower limit) to 29.00 pg/mL (upper limit).

Conclusions:

• Proposed reference values for plasma Aβ_1-42 in cognitively normal individuals.
• Further research is required to validate these findings for clinical practice.
• These reference values could aid in the diagnostic utility of Aβ_1-42 for Alzheimer's disease.