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Plasma β-amyloid1-42 reference values in cognitively normal subjects.

Chiara Zecca1, Rosanna Tortelli2, Francesco Panza3

  • 1Unit of Laboratory Medicine, Pia Fondazione Card.G. Panico, Tricase, Lecce, Italy; Unit of Neurodegenerative Disease, Department of Clinical Research in Neurology, University of Bari "Aldo Moro" at "Pia Fondazione Card. G. Panico", Tricase, Lecce, Italy.

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Summary

This study established reference values for plasma beta-amyloid 1-42 (Aβ1-42) in cognitively normal individuals. Results show Aβ1-42 levels increase with age, providing crucial data for Alzheimer's disease biomarker use.

Keywords:
Alzheimer's diseaseAβ peptideBiomarkerPlasmaReference valuesβ-amyloid

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Clinical Diagnostics

Background:

  • Plasma beta-amyloid 1-42 (Aβ1-42) is a potential Alzheimer's disease biomarker.
  • Clinical application is hindered by a lack of established reference values.
  • This study aimed to determine Aβ1-42 plasma concentrations in healthy individuals.

Purpose of the Study:

  • To evaluate plasma Aβ1-42 concentrations in cognitively normal subjects.
  • To propose reference values for plasma Aβ1-42 for clinical use.

Main Methods:

  • Analyzed plasma samples from 245 subjects aged 19-89 years.
  • Categorized participants into three age groups: young (≤34), adult (35-64), and old (>64).
  • Utilized the Innogenetics Elisa kit for plasma Aβ1-42 quantification.

Main Results:

  • The mean plasma Aβ1-42 concentration was 17.65 (5.71) pg/mL.
  • A significant positive trend in Aβ1-42 levels was observed across age groups (p < .0001).
  • Established 90% reference interval for the cohort: 8.12 pg/mL (lower limit) to 29.00 pg/mL (upper limit).

Conclusions:

  • Proposed reference values for plasma Aβ1-42 in cognitively normal individuals.
  • Further research is required to validate these findings for clinical practice.
  • These reference values could aid in the diagnostic utility of Aβ1-42 for Alzheimer's disease.