Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is an Ecosystem?01:17

What is an Ecosystem?

47.1K
Overview
47.1K
The Soil Ecosystem02:23

The Soil Ecosystem

24.8K
Plants obtain inorganic minerals and water from the soil, which acts as a natural medium for land plants. The composition and quality of soil depend not only on the chemical constituents but also on the presence of living organisms. In general, soils contain three major components:
24.8K
Actin Treadmilling01:18

Actin Treadmilling

9.7K
Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...
9.7K
Nuclear Stability03:18

Nuclear Stability

23.3K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.3K
RNA Stability01:53

RNA Stability

35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
Stability01:28

Stability

421
The time response of a linear time-invariant (LTI) system can be divided into transient and steady-state responses. The transient response represents the system's initial reaction to a change in input and diminishes to zero over time. In contrast, the steady-state response is the behavior that persists after the transient effects have faded.
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
421

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contractile forces direct the chiral swirling of minimal cell collectives.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.

EMBO reports·2025
Same author

Microtubule-driven cell shape changes and actomyosin flow synergize to position the centrosome.

The Journal of cell biology·2025
Same author

The actin protrusion deforms the nucleus during invasion through basement membrane.

bioRxiv : the preprint server for biology·2025
Same author

Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation.

Developmental cell·2024
Same author

Heterotypic interaction promotes asymmetric division of human hematopoietic progenitors.

Development (Cambridge, England)·2024

Related Experiment Video

Updated: Feb 6, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
08:57

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

8.4K

Dynamic stability of the actin ecosystem.

Julie Plastino1,2, Laurent Blanchoin3,4

  • 1Institut Curie, PSL Research University, CNRS, 75005 Paris, France julie.plastino@curie.fr laurent.blanchoin@cea.fr.

Journal of Cell Science
|August 15, 2018
PubMed
Summary

Cells maintain a dynamic steady state of actin filaments, balancing assembly and disassembly. This plasticity allows rapid adaptation to environmental changes, crucial for cellular function.

Keywords:
ActinCytoskeletonSteady state

More Related Videos

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM
19:16

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM

Published on: August 5, 2009

16.5K
Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

3.8K

Related Experiment Videos

Last Updated: Feb 6, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
08:57

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

8.4K
Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM
19:16

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM

Published on: August 5, 2009

16.5K
Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

3.8K

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Actin filaments form a dynamic cytoskeleton in cells, continuously assembling and disassembling.
  • This dynamic process maintains a stable network structure, operating far from equilibrium via ATP hydrolysis.
  • This behavior is termed a dynamic steady state, conferring plasticity to the cytoskeleton.

Purpose of the Study:

  • To review current knowledge of the cellular actin steady state.
  • To identify gaps in understanding this fundamental dynamic process.
  • To explore the minimal steps, feedback mechanisms, and molecular nature of the actin steady state.

Main Methods:

  • Literature review of actin dynamics and cytoskeleton regulation.
  • Analysis of theoretical models for dynamic steady states.
  • Discussion of experimental evidence for actin organization and plasticity.

Main Results:

  • The actin steady state balances filament assembly and disassembly, enabling cellular adaptation.
  • Cytoskeleton plasticity allows cells to respond to external stimuli on short timescales.
  • Key feedback mechanisms and minimal requirements for achieving steady state are discussed.

Conclusions:

  • Understanding the actin steady state is crucial for comprehending cellular adaptation and function.
  • Further research is needed to fully elucidate the molecular basis of this dynamic process.
  • Identifying remaining gaps will guide future investigations into cytoskeleton regulation.