Related Experiment Video
Updated: Feb 6, 2026
10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
4.1K
CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma
Walaa Hamed Shaker Nasry1, Haili Wang2, Kathleen Jones3
1Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada. wnasry@upei.ca.
Veterinary Sciences
|August 15, 2018
Summary
Cluster of differentiation 147 (CD147) is expressed in feline oral squamous cell carcinoma (OSCC) tumors. This study suggests CD147 may be a novel therapeutic target for feline OSCC.
Area of Science:
- Veterinary Oncology
- Cancer Biology
Background:
- Feline oral squamous cell carcinoma (OSCC) is an aggressive cancer in cats.
- Cluster of differentiation 147 (CD147) is implicated in human OSCC invasiveness and inflammation.
- CD147 expression in feline OSCC has not been previously investigated.
Purpose of the Study:
- To investigate the expression and potential coordination of CD147 and cyclooxygenase 2 (COX-2) in feline OSCC.
- To evaluate CD147 as a potential therapeutic target in feline OSCC.
Main Methods:
- Immunohistochemistry was employed to assess CD147 and COX-2 expression in feline OSCC biopsies.
- Gene expression of CD147 and COX-2 was analyzed in feline OSCC cell lines.
- Correlation between CD147, COX-2, and prostaglandin E2 (PGE2) secretion was examined.
Main Results:
- CD147 and COX-2 were significantly more expressed in feline OSCC tumor cells compared to stroma and adjacent epithelium.
- CD147 gene expression was consistent across feline OSCC cell lines, unlike COX-2.
- CD147 expression did not correlate with COX-2 expression or PGE2 secretion, suggesting independent regulation.
Conclusions:
- CD147 is expressed in feline OSCC and may play a role independent of COX-2.
- CD147 represents a promising novel therapeutic target for feline OSCC.
- Further research into CD147's role in feline OSCC is warranted.
Related Concept Videos
01:58Cell Specific Gene Expression
16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
01:58Cell Specific Gene Expression
5.6K
5.6K
01:11Oral Cavity
3.2K
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.2K
02:35Chromatin Position Affects Gene Expression
24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
01:42What is Gene Expression?
196.9K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.9K
01:06Oral Hypoglycemic Agents: Glinides
674
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
674