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Related Experiment Videos

Chemonucleolysis (discolysis) with collagenase.

M D Brown, J S Tompkins

    Spine
    |March 1, 1986
    PubMed
    Summary

    Intradiscal collagenase injections for lumbar disc displacement showed a 72% success rate. This treatment for herniated discs was safe and effective, particularly for older males with chronic pain.

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    In Memoriam: Olga Hudlická (11.07.26-03.05.14).

    Microcirculation (New York, N.Y. : 1994)·2014

    Area of Science:

    • Orthopedics
    • Neurosurgery
    • Biochemistry

    Background:

    • Lumbar disc displacement is a common cause of low back pain.
    • Intradiscal collagenase injections offer a minimally invasive treatment option.

    Observation:

    • Fifty-four patients with lumbar disc displacement received intradiscal collagenase (Nucleolysin) injections.
    • Follow-up included history, physical examination, and surveys.

    Findings:

    • A 72% success rate was observed, with no adverse events.
    • Older patients (>50 years), males, and those with chronic pain (>4 months) showed higher success rates.
    • Specific physical exam findings (e.g., limited straight leg raise) predicted poorer outcomes.
    • Pre-injection discography and post-injection CT scans did not negatively impact outcomes.
    • Surgery outcomes were not compromised by prior failed collagenase treatment.

    Implications:

    • Intradiscal collagenase is a potentially effective and safe treatment for lumbar disc displacement.
    • Patient selection and specific clinical indicators can help predict treatment success.
    • This enzyme therapy does not preclude future surgical interventions if necessary.

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