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Updated: Feb 6, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.0K

His bundle pacing

Jason Payne1, Ann C Garlitski1, Jonathan Weinstock1

  • 1The New England Cardiac Arrhythmia Center, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Boston, MA, 02111, USA.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|August 15, 2018
PubMed

Insights

His bundle pacing (HBP) offers physiologic ventricular activation, potentially correcting conduction issues. Current data suggest HBP is a safe and effective alternative to traditional pacing methods.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Right ventricular apical pacing can lead to adverse effects.
  • His bundle pacing (HBP) is an alternative pacing technique.
  • HBP aims for more physiologic ventricular activation.

Purpose of the Study:

  • To review the physiology of the His bundle (HB) in relation to HBP.
  • To describe current clinical experience with HBP.
  • To discuss future directions for HBP therapy.

Main Methods:

  • Review of existing literature on His bundle pacing.
  • Analysis of observational clinical data.
  • Discussion of physiological principles.

Main Results:

  • HBP provides physiologic ventricular activation.
  • HBP may correct underlying conduction abnormalities.
  • Observational data support HBP's safety and efficacy.

Conclusions:

  • His bundle pacing is an emerging therapy with demonstrated safety and efficacy.
  • HBP offers advantages over traditional right ventricular pacing.
  • Further large-scale trials are anticipated.

Keywords:
AV blockCardiac resynchronizationHis bundle pacingLongitudinal dissociation

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