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Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
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Phencyclidine-Based New Psychoactive Substances.

Jason Wallach1, Simon D Brandt2

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This summary is machine-generated.

Phencyclidine (PCP) analogs have evolved from early research compounds to street drugs. Recent years show a rise in novel PCP-derived new psychoactive substances (NPS) with unique pharmacology.

Keywords:
ClinicalDesigner drugsDissociativesForensicNMDA receptorNPSPharmacologyPhencyclidineToxicology

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Area of Science:

  • Pharmacology and Toxicology
  • Neuroscience
  • Medicinal Chemistry

Background:

  • Phencyclidine (PCP), discovered in 1956, is a prototypical dissociative agent with numerous analogs developed for research.
  • PCP and its early analogs became recognized as street drugs between the 1960s and 1990s.
  • The internet facilitated the emergence of new PCP analogs in the 2000s, including novel compounds not previously documented.

Purpose of the Study:

  • To provide an overview of recently emerged PCP-derived new psychoactive substances (NPS).
  • To discuss the known pharmacology of these novel PCP analogs.
  • To include data on related analogs, focusing on N-methyl-D-aspartate receptor (NMDAR) antagonism.

Main Methods:

  • Literature review of scientific publications and drug databases.
  • Analysis of reported pharmacology, particularly NMDAR antagonism.
  • Comparison of novel NPS with previously known PCP analogs.

Main Results:

  • A significant number of novel PCP-derived NPS have appeared since the 2000s, some not previously described in scientific literature.
  • NMDAR antagonism is a key mechanism underlying the psychoactive effects of many dissociative drugs, including these new analogs.
  • Pharmacological data from related analogs are presented to contextualize the NPS.

Conclusions:

  • The landscape of PCP analogs has expanded significantly with the advent of novel NPS.
  • Understanding the pharmacology, especially NMDAR interactions, is crucial for characterizing these substances.
  • Continued research is necessary to monitor and understand the emergence and effects of these new psychoactive substances.