Contribution of arachidonic acid metabolites to atherosclerosis

Evidence is presented that arachidonic acid metabolites are involved to an important extent in platelet-arterial wall interaction. The perspectives opened up by these results are the possible prevention and therapy of atherosclerosis by a fish-diet containing eicosapentaenoic acid, the use of prostaglandins, releasers of endogenous PGI2 and thromboxane synthetase inhibitors.