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Updated: Feb 6, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

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Published on: November 25, 2011

A tissue-engineered rostral migratory stream for directed neuronal replacement.

John C O'Donnell¹, Kritika S Katiyar², Kate V Panzer³

¹Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.

Neural Regeneration Research

|August 15, 2018

Summary

Researchers engineered a microtissue that mimics the brain's rostral migratory stream, promoting new neuron growth. This innovation offers potential for sustained neuronal replacement after brain injury and neurodegenerative diseases.

Keywords:

astrocyte brain injury glial tube neural regeneration neural repair neuroblast rostral migratory stream tissue engineering

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Last Updated: Feb 6, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

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Published on: May 30, 2016

Area of Science:

Neuroscience
Tissue Engineering
Regenerative Medicine

Background:

Adult neurogenesis occurs in the mammalian brain, particularly in the olfactory bulb.
New neurons migrate via the rostral migratory stream (RMS), a structure whose mechanisms are not fully understood.
Brain injury regeneration is limited, with insufficient neuronal replacement to restore function.

Purpose of the Study:

To develop an in vitro model of the RMS using microtissue engineering.
To investigate neuroblast migration and maturation.
To explore potential therapeutic applications for brain injury and neurodegenerative diseases.

Main Methods:

Utilized novel microtissue engineering techniques to create self-contained, implantable constructs.
Engineered microtissue that emulates the glial tube architecture of the native RMS.
Fabricated living microtissue-engineered RMS constructs.

Main Results:

The engineered microtissue successfully mimics the architecture and function of the native RMS.
Demonstrated proof-of-principle that the microtissue promotes and directs immature neuron migration.
The construct serves as a viable in vitro test bed for studying neuroblast behavior.

Conclusions:

Developed the first microtissue-engineered RMS, replicating key features of the natural structure.
This engineered RMS can be used to study neuroblast migration and maturation.
Potential exists for using patient-derived cells in transplantable constructs for sustained neuronal replacement therapy.