Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavior of Concrete Under Compressive Load01:23

Behavior of Concrete Under Compressive Load

643
Concrete exhibits specific behaviors under different compressive loads. Understanding this is crucial for understanding its structural integrity. When concrete undergoes uniaxial compression, it tends to develop cracks that run parallel to the direction of the force. These parallel cracks stem from localized tensile stresses that occur perpendicular to the compression direction. Additionally, angled cracks may appear due to the formation of shear planes.
As the concrete specimen fractures under...
643
Relation Between Tensile Strength and Compressive Strength of Concrete01:30

Relation Between Tensile Strength and Compressive Strength of Concrete

685
Concrete is a fundamental building material, and understanding its strengths is crucial for construction projects. The relationship between its tensile and compressive strengths is intricate, showing that while these strengths are related, they do not increase at the same rate. Tensile strength's growth is slower and is affected by various factors such as the methods used for testing, the size and shape of the specimen, the texture of the aggregate used, and the moisture content of the...
685
Chronic Pharyngitis01:23

Chronic Pharyngitis

12.2K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
12.2K
Density, Specific Weight, Specific Gravity and Compressibility of Fluid01:27

Density, Specific Weight, Specific Gravity and Compressibility of Fluid

1.7K
Density, specific weight, specific gravity, and compressibility are fundamental properties of fluids. Density is the mass per unit volume, characterizing the mass of a fluid system. It influences buoyancy, pressure, flow dynamics, viscosity, thermal conductivity, and sound propagation. For instance, in pipeline design, accurate density measurements ensure that the pipeline can handle the fluid's mass.
Specific weight represents the weight per unit volume and is calculated by multiplying...
1.7K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

745
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
745
Spinal Nerves: Plexus II01:21

Spinal Nerves: Plexus II

2.5K
The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between blood pressure levels and mortality in patients with type 2 diabetes: A retrospective cohort analysis.

Journal of diabetes investigation·2026
Same author

Ultrasound measurement of left ventricular function and structural indicators and gender-age differences in type 2 diabetes mellitus.

Heart & lung : the journal of critical care·2026
Same author

SLC31A1 exon 1 methylation reduces intracellular copper ion and promotes diabetic cardiac fibrosis.

Cardiovascular diabetology·2026
Same author

Association of the C-reactive protein-triglyceride-glucose index with metabolic dysfunction-associated steatotic liver disease and long-term all-cause and cardiovascular mortality: evidence from two nationwide prospective cohort studies.

Cardiovascular diabetology·2026
Same author

Establishment of a human induced pluripotent stem cell line (BTHBIOi005-A) from a retinitis pigmentosa patient with a MERTK gene mutation.

Stem cell research·2026
Same author

Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood-Brain Barrier Integrity.

Circulation·2026

Related Experiment Video

Updated: Feb 6, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
08:23

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

60.6K

A novel chronic nerve compression model in the rat.

Zhen-Yu Liu1, Zhen-Bing Chen1, Jiang-Hai Chen1

  • 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Neural Regeneration Research
|August 15, 2018
PubMed
Summary

This study introduces a novel chronic sciatic nerve compression model in rats, mimicking human nerve injuries. The model effectively induces demyelination, muscle atrophy, and functional deficits, offering a more reliable research tool.

Keywords:
N-butyl-cyanoacrylateaxonal irregularitycarpal tunnel syndromechronic nerve compressioncollagen depositiondemyelinationhypoesthesiaintrinsic musclesnerve conduction velocitynerve regenerationneural regenerationremyelination

More Related Videos

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
09:39

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Published on: July 14, 2020

8.7K
Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain
08:20

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Published on: June 30, 2023

2.7K

Related Experiment Videos

Last Updated: Feb 6, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
08:23

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

60.6K
Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
09:39

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Published on: July 14, 2020

8.7K
Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain
08:20

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Published on: June 30, 2023

2.7K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Animal Models

Background:

  • Current animal models for chronic peripheral nerve compression often use silicone tubes, which may not accurately reflect the non-uniform sciatic nerve anatomy.
  • Individual variations in sciatic nerve diameter can affect the reliability of existing compression models.

Purpose of the Study:

  • To develop and validate a novel, reliable chronic sciatic nerve compression model in rats.
  • To establish a model that replicates functional and histological changes observed in human chronic nerve compression injuries.

Main Methods:

  • A new compression model was created using latex glove pieces and N-butyl-cyanoacrylate around the rat sciatic nerve.
  • Functional assessments included hot plate tests and electromyography.
  • Histological analyses involved immunofluorescence, electron microscopy, and Masson staining to evaluate nerve damage and fibrosis.

Main Results:

  • The novel model induced thermal hypoesthesia and decreased nerve conduction velocity in pups within 2 weeks.
  • Histopathology revealed nerve demyelination, axonal irregularities, and collagen deposition by 8 weeks.
  • Significant muscle fibrosis was observed in the gastrocnemius and paw muscles at 20 weeks post-compression.

Conclusions:

  • The developed rat sciatic nerve compression model successfully reproduces key functional and histological hallmarks of chronic nerve compression injury.
  • This model serves as a valuable tool for future research into the mechanisms of chronic nerve compression and potential therapeutic interventions.