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CRISPR-Mediated Reorganization of Chromatin Loop Structure
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Looping Star.

Florian Wiesinger1,2, Anne Menini1, Ana Beatriz Solana1

  • 1ASL Europe, GE Healthcare, Munich, Germany.

Magnetic Resonance in Medicine
|August 15, 2018
PubMed
Summary
This summary is machine-generated.

Introducing Looping Star, a novel MRI pulse sequence for fast, quiet, and robust 3D T2* imaging. This advanced technique offers new possibilities for T2*-weighted imaging, mapping, and functional MRI (fMRI).

Keywords:
BURSTLooping StarQSMQuietRUFISSilentT2*UTEfMRI

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Physics

Background:

  • T2* imaging is crucial for various applications, but conventional methods can be slow, noisy, or susceptible to artifacts.
  • There is a need for advanced MRI techniques that offer speed, robustness, and reduced acoustic noise.

Purpose of the Study:

  • To introduce a novel Magnetic Resonance Imaging (MRI) pulse sequence, named Looping Star.
  • To enable fast, robust, and quiet 3D radial multi-gradient echo T2* imaging.

Main Methods:

  • The Looping Star sequence builds upon the 3D radial Rotating Ultra-Fast Imaging Sequence (RUFIS).
  • It incorporates a time-multiplexed gradient-refocusing mechanism to create a looping k-space trajectory.
  • This allows for capturing initial Free Induction Decay (FID) images and subsequent gradient echo images at equidistant echo times.

Main Results:

  • Looping Star was successfully demonstrated in phantom and in vivo experiments for high-resolution 3D T2* imaging, T2* mapping, and quantitative susceptibility mapping (QSM).
  • The sequence proved to be fast, quiet, and robust against artifacts like Eddy currents, motion, and geometric distortions.
  • In a motor task functional MRI (fMRI) experiment, a Blood-Oxygen-Level-Dependent (BOLD) sensitivity of 5% was achieved with minimal acoustic noise.

Conclusions:

  • Looping Star imaging presents significant advancements for T2* MRI, offering speed, robustness, and quiet operation.
  • Potential applications include enhanced T2*-weighted imaging, T2* mapping, QSM, and fMRI.