Related Experiment Video
Updated: Feb 6, 2026
09:03
Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
Published on: March 28, 2025
1.2K
A pharmacogenetics approach to pain management
Kaori Yoshida1,2, Daisuke Nishizawa1, Soichiro Ide1
1Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Neuropsychopharmacology Reports
|August 15, 2018
Summary
Individual differences in opioid effectiveness are significant for pain management. Genetic factors, specifically gene polymorphisms, are key to understanding and personalizing opioid analgesic requirements for better patient outcomes.
Area of Science:
- Pharmacogenomics
- Pain Management
- Genetics
Background:
- Opioid analgesics are crucial for moderate-to-severe pain.
- Individual responses to opioid analgesics vary significantly.
- Genetic factors are increasingly recognized as influencing these variations.
Purpose of the Study:
- To review the association between opioid analgesic requirements and gene polymorphisms.
- To highlight the role of genetics in personalized pain treatment.
Main Methods:
- Review of scientific literature on opioid analgesics and gene polymorphisms.
- Analysis of genetic factors influencing opioid efficacy.
Main Results:
- Gene polymorphisms significantly impact individual opioid analgesic requirements.
- Understanding these genetic associations is vital for effective pain management.
Conclusions:
- Personalized pain treatment strategies are emerging based on gene polymorphism data.
- Further research in this area promises improved pain management in the future.
Related Concept Videos
01:25Analgesia and Pain Management
1.7K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.7K
01:20Pain
1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
01:20Frustration and Conflict: Approach-Approach, Approach-Avoidance
539
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
539
01:26Tonsillitis II: Management
438
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
438
01:29Impression Management Techniques I: Managing Appearances
220
Appearance is a multidimensional aspect of self-presentation that encompasses observable attributes such as clothing, grooming, speech, and nonverbal behavior. These elements are often strategically managed to align with socially constructed expectations in different settings. For instance, individuals tailor their appearance during job interviews, social gatherings, or athletic events to meet the perceived norms of those environments.Contextual Adaptation and Social SignalsThe research...
220
01:19Managing Impressions
173
Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...
173