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Long non‑coding RNAs in small cell lung cancer: A potential opening to combat the disease (Review)
Tian-Tian Li1, Rong-Quan He2, Jie Ma2
1Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Abstract:
Lung cancer is the top cause of cancer‑associated mortality in men and women worldwide. Small cell lung cancer (SCLC) is a subtype that constitutes ~15% of all lung cancer cases. Long non‑coding RNAs (lncRNAs), possessing no or limited protein‑coding ability, have gained extensive attention as a potentially promising avenue by which to investigate the biological regulation of human cancer. lncRNAs can modulate gene expression at the transcriptional, post‑transcriptional and epigenetic levels. The current review highlights the developing clinical implications and functional roles of lncRNAs in SCLC, and provides directions for their future utilization in the diagnosis and treatment of SCLC.
Insights
Long non-coding RNAs (lncRNAs) are key regulators in small cell lung cancer (SCLC). This review explores their roles in SCLC, offering insights for novel diagnostic and therapeutic strategies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Lung cancer is a leading cause of cancer mortality globally.
- Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancer cases.
- Long non-coding RNAs (lncRNAs) are emerging as critical regulators in cancer biology.
Purpose of the Study:
- To review the functional roles of lncRNAs in SCLC.
- To highlight the clinical implications of lncRNAs in SCLC.
- To provide future directions for lncRNA-based diagnosis and treatment of SCLC.
Main Methods:
- Literature review of studies on lncRNAs in SCLC.
- Analysis of lncRNA functions at transcriptional, post-transcriptional, and epigenetic levels.
- Synthesis of current clinical applications and future potential of lncRNAs.
Main Results:
- lncRNAs play significant roles in the biological regulation of SCLC.
- lncRNAs can influence gene expression through various mechanisms.
- Evidence suggests lncRNAs have potential as biomarkers and therapeutic targets in SCLC.
Conclusions:
- lncRNAs represent a promising area for understanding and combating SCLC.
- Further research into lncRNA mechanisms can lead to improved diagnostic tools.
- Targeting lncRNAs may offer new therapeutic avenues for SCLC patients.
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