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Related Concept Videos

The Replisome03:01

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
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Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
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Related Experiment Video

Updated: Feb 6, 2026

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion
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Replisome-Cohesin Interfacing: A Molecular Perspective.

Sara Villa-Hernández1, Rodrigo Bermejo1

  • 1Centro de Investigaciones Biológicas (CIB-CSIC), Calle Ramiro de Maeztu 928040 Madrid, Spain.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|August 15, 2018
PubMed
Summary
This summary is machine-generated.

Cohesin complexes entrap nascent chromatids during DNA replication, ensuring sister chromatid cohesion. This process is crucial for accurate chromosome segregation and DNA repair.

Keywords:
DNA replicationchromosome dynamicsreplication forks, cohesinreplisome structuresister chromatid cohesion

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Sister chromatid cohesion, established in S-phase, is vital for genome stability.
  • Cohesin molecules are key to maintaining this cohesion, facilitating DNA repair and segregation.
  • The precise mechanisms of cohesin's interaction with replicating DNA remain incompletely understood.

Purpose of the Study:

  • To elucidate the structural features of cohesin relevant to DNA binding.
  • To review recent advancements in understanding the eukaryotic replisome's organization.
  • To discuss models for cohesin's engagement with replication forks and nascent chromatids.

Main Methods:

  • Structural analysis of the cohesin complex.
  • Biochemical studies of replisome architecture.
  • Review of current literature on DNA replication and cohesion.

Main Results:

  • Cohesin possesses essential structural properties for DNA association.
  • Recent studies have significantly advanced knowledge of eukaryotic replisome organization.
  • Proposed mechanisms detail how replication forks interface with cohesin.

Conclusions:

  • Understanding cohesin's structural and functional roles is advancing.
  • Novel insights into replisome-cohesin interactions are emerging.
  • Models for nascent chromatid entrapment by cohesin are being refined.