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Updated: Feb 6, 2026

Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature
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Digital-Facial Translocation in Amniotic Band Sequence: Evidence of the Intrinsic Theory

Brielle Weinstein1, Mahmoud Hassouba2, Roberto L Flores3

  • 1Division of Plastic Surgery, University of South Florida, Tampa, FL.

The Journal of Craniofacial Surgery
|August 15, 2018
PubMed

Insights

A novel variation of amniotic band sequence involves craniofacial clefting and limb anomalies. This presentation supports theories linking embryonic mesenchyme exposure to amniotic band syndrome etiology.

Area of Science:

  • Developmental Biology
  • Congenital Anomalies
  • Medical Genetics

Background:

  • Amniotic band sequence is a congenital anomaly.
  • It typically involves limb and digit constriction by amniotic tissue.
  • Genetic mutations are usually not implicated.

Observation:

  • Three patients presented with complex craniofacial clefting and amniotic band sequence.
  • Hypertelorism and varied craniofacial clefts were observed.
  • Bands connected hands to facial clefts, with digital-facial translocation in two cases.

Findings:

  • Complex craniofacial clefts may expose embryonic mesenchyme.
  • This exposed mesenchyme can adhere to ipsilateral fetal hands.
  • This supports intrinsic and adhesion theories of amniotic band syndrome.

Implications:

  • Provides a new model for understanding amniotic band sequence etiology.
  • Highlights the link between craniofacial development and limb anomalies.
  • Suggests potential for improved diagnostic and therapeutic approaches.

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