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Predictors of Severe Clinical Course in Children With Carbon Monoxide Poisoning

Leman Akcan Yildiz1, Ayse Gultekingil1, Selman Kesici2

  • 1From the Division of Pediatric Emergency Medicine.

Pediatric Emergency Care
|August 15, 2018
PubMed

Insights

Carbon monoxide poisoning in children can be severe. Low Glasgow Coma Scale scores, high leukocyte counts, and elevated troponin T levels indicate a higher risk for a severe clinical course.

Area of Science:

  • Pediatric Emergency Medicine
  • Toxicology
  • Environmental Health

Background:

  • Carbon monoxide (CO) poisoning is a significant cause of injury from incomplete combustion.
  • Acute CO poisoning can lead to severe organ damage.

Purpose of the Study:

  • To evaluate demographic, clinical, and laboratory features of pediatric CO poisoning.
  • To identify predictors of severe disease course in acute CO poisoning.

Main Methods:

  • Retrospective analysis of 331 pediatric CO poisoning cases.
  • Inclusion of demographic data, clinical findings, Glasgow Coma Scale (GCS) scores, and laboratory results (carboxyhemoglobin, leukocyte count, troponin T, lactate).
  • Assessment of treatment modalities (normobaric/hyperbaric oxygen) and outcomes (PICU admission, mortality).

Main Results:

  • 18 patients experienced a severe clinical course, and 6 patients died.
  • Risk factors for severe disease included low GCS scores, elevated leukocyte counts, and high troponin T levels.
  • Hyperbaric oxygen was administered to 93 patients, and 51 were admitted to the pediatric intensive care unit.

Conclusions:

  • GCS score, leukocyte count, and troponin T levels are potential predictors of clinical outcomes in pediatric CO poisoning.
  • These markers can aid in tailoring treatment strategies for children with CO poisoning.
Abstract

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