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Updated: Feb 6, 2026

A Conflict Model of Reward-seeking Behavior in Male Rats
Published on: February 20, 2019
Inter-subject correlation of temporoparietal junction activity is associated with conflict patterns during flexible
Shisei Tei1, Jukka-Pekka Kauppi2, Junya Fujino3
1Department of Psychiatry, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan; Institute of Applied Brain Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama, 359-1192, Japan; School of Human and Social Sciences, Tokyo International University, Saitama, 350-1198, Japan; Medical Institute of Developmental Disabilities Research, Showa University Karasuyama Hospital, Tokyo 157-8577, Japan.
Abstract:
Although behavioral flexibility and conflict regulation may rely on executive function, the mechanism underlying these relationships remains obscure. We studied whether subjects' conflict ratings were associated with right dorsolateral prefrontal cortex (rDLPFC) and temporoparietal junction (rTPJ) activity during flexible decision-making in a moral dilemma task using inter-subject correlation (ISC)-based approach (i.e., brain-behavior correlation matrices analysis). We observed a statistically significant positive correlation between the ISC matrix of rTPJ and conflict-scores. This implies that similar rTPJ activity patterns across subjects were associated with similar conflict-rating patterns across subjects. Our findings suggest that rTPJ activity may be also related to conflicting experience.
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