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Updated: Feb 6, 2026

Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
Technical challenges of lung transplantation in children after arterial switch operation
Thomas Martens1,2, Martin Kostolny1,3, Helen Spencer4
1Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Abstract:
Pulmonary arterial hypertension after arterial switch operation for transposition of the great arteries is rare. Lung transplantation can be the last option in cases of failed medical therapy. We report 2 paediatric patients who underwent lung transplantation for this indication. Altered hilar anatomy, mediastinal adhesions and haemostatic control represent the main technical challenges. Volume-reduction surgery is sometimes necessary to address altered cardiopulmonary relationships while expanding the donor pool.
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