[Ovarian clear cell borderline tumour: a clinicopathologic analysis]

Area of Science:

• Gynecologic Oncology
• Pathology
• Reproductive Medicine

Background:

• Ovarian clear cell borderline tumors (OCCBTs) are rare neoplasms.
• Understanding their clinical and pathological features is crucial for accurate diagnosis and management.

Purpose of the Study:

• To investigate the clinical and pathological characteristics of OCCBTs.
• To evaluate the prognosis and identify potential associated factors of OCCBTs.

Main Methods:

• Retrospective review of 12 OCCBT cases diagnosed between May 2011 and December 2017.
• Analysis of clinical histories and pathological slides, including immunohistochemical staining for CK7, HNF-1β, Naspin A, ARID1A, and p53.

Main Results:

• The mean patient age was 52 years (range 35-65).
• Seven cases were associated with ovarian cystic endometriosis.
• Immunohistochemistry revealed CK7 and HNF-1β positivity in all cases, Naspin A in 11/12, absent ARID1A in 5/12, and wild-type p53.
• No recurrence was observed during follow-up (7-79 months).

Conclusions:

• OCCBTs may be associated with endometriosis and alterations in tumor suppressor gene ARID1A.
• OCCBTs demonstrate a favorable prognosis with no evidence of recurrence or malignant transformation.