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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction

Peter Blomstrand1,2, Peter Sjöblom3,4, Mats Nilsson5

  • 1Department of Clinical Physiology, County Hospital Ryhov, Jönköping, Sweden. peter.blomstrand@rjl.se.

Cardiovascular Diabetology
|August 16, 2018
PubMed

Insights

Overweight and obesity negatively impact left ventricular systolic function, specifically ejection fraction and global longitudinal strain, in individuals with and without type 2 diabetes mellitus. Weight changes further influence these cardiac parameters.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Echocardiography

Background:

  • Obesity is linked to type 2 diabetes mellitus and cardiovascular issues like diastolic dysfunction and heart failure.
  • The specific impact of obesity on left ventricular systolic dysfunction remains less clear.

Purpose of the Study:

  • To investigate the effects of overweight and obesity on left ventricular systolic function.
  • To compare these effects in patients with type 2 diabetes mellitus and a non-diabetic control group.

Main Methods:

  • Prospective study of 384 type 2 diabetes mellitus patients and 184 controls, grouped by BMI (normal, overweight, obese).
  • Echocardiography performed at baseline and after 4 years in the diabetic group.
  • Regression analysis used to assess relationships between BMI and left ventricular function parameters.

Main Results:

  • Body mass index correlated with left ventricular ejection fraction, global longitudinal strain, and left ventricular mass in both groups.
  • Obesity was associated with reduced left ventricular ejection fraction and global longitudinal strain compared to normal weight.
  • Weight gain correlated with decreased ejection fraction, while weight loss correlated with improvement.

Conclusions:

  • Overweight and obesity demonstrably impair left ventricular systolic function (ejection fraction and global longitudinal strain).
  • These effects are observed in both type 2 diabetes mellitus patients and non-diabetic individuals.
  • Findings highlight the cardiovascular risks associated with excess weight, irrespective of diabetic status.
Abstract

Keywords:
Diabetes mellitusEchocardiographyObesityOverweight

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