Related Experiment Video
Updated: Feb 6, 2026

Preparation of High-Temperature Sample Grids for Cryo-EM
Published on: July 26, 2021
Author Correction: Cryo-EM structure of a fungal mitochondrial calcium uniporter
Nam X Nguyen1,2, Jean-Paul Armache3, Changkeun Lee1,2,4
1Howard Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abstract:
In this Article, ref. 15 has been replaced and references 32 to 50 have been renumbered online.
Insights
This study involved minor reference updates for accuracy. The article now includes a replaced reference and renumbered citations for improved scholarly integrity.
Area of Science:
- Structural Biology and high-resolution Cryo-Electron Microscopy.
- Mitochondrial Physiology and the fungal mitochondrial calcium uniporter.
Background:
Scientific publishing requires rigorous adherence to citation standards to maintain the integrity of the scholarly record. Prior research has shown that accurate bibliographic data allows researchers to trace the development of structural models and experimental protocols effectively. In the context of high-resolution imaging, the precise attribution of previous findings regarding mitochondrial transport proteins is essential for contextualizing new structural data. The original publication regarding the fungal mitochondrial calcium uniporter contained specific errors in its reference list that required formal amendment to ensure clarity. Maintaining a clear and error-free connection between current findings and established literature ensures that the scientific community can verify the evidence base. This absence of evidence motivated the editorial team and the authors to issue a formal correction to the online version of the article.
Purpose Of The Study:
The primary objective of this formal amendment involves the rectification of specific bibliographic inaccuracies within the original manuscript. The authors sought to replace reference 15 to ensure that the cited work accurately reflects the intended scientific context of the study. This effort also aimed to renumber references 32 through 50 to maintain a logical and sequential flow throughout the online text. Correcting these citations is necessary to prevent confusion among readers who are examining the structural details of the mitochondrial calcium transport system. By updating the digital record, the researchers ensure that the scholarly lineage of the fungal mitochondrial calcium uniporter remains transparent and verifiable. This effort focuses on upholding the high standards of accuracy expected in structural biology publications and digital archives.
Main Methods:
The investigative process for this correction involved a comprehensive review of the citation list associated with the Cryo-EM structure. The editorial staff and authors identified that reference 15 required immediate replacement with a more appropriate or accurate source for the reported data. Subsequently, a systematic renumbering protocol was applied to the references spanning from 32 to 50 in the online version of the article. This digital adjustment ensures that every citation within the text corresponds correctly to the final bibliography provided at the end of the paper. The researchers utilized the journal's online publishing platform to implement these changes across the entire document, ensuring that the digital record remains consistent. These specific technical steps were taken to preserve the utility of the reference list for the global scientific community.
Main Results:
The primary result of this action is the successful replacement of reference 15 within the corrected version of the manuscript. The online text now features a renumbered sequence for references 32 through 50, ensuring bibliographic consistency across the entire report. These modifications allow for a seamless reading experience where the citations align perfectly with the supporting evidence for the fungal mitochondrial calcium uniporter structure. The structural data obtained through Cryo-EM remains unchanged and continues to provide a high-resolution view of the mitochondrial calcium uniporter. No alterations were made to the primary experimental findings or the structural models presented in the original report. The correction successfully addresses the identified clerical errors without impacting the scientific conclusions regarding fungal mitochondrial physiology.
Conclusions:
The authors conclude that the updated reference list provides a more accurate and reliable foundation for the reported structural findings. These bibliographic corrections are essential for researchers who rely on the fungal mitochondrial calcium uniporter data for subsequent studies in mitochondrial biology. By ensuring that reference 15 and the sequence from 32 to 50 are correct, the authors maintain the trustworthiness of the published record. Future investigations into the mechanism of calcium transport can now proceed with a clear understanding of the relevant literature. The researchers emphasize that the integrity of the Cryo-EM structure remains the focal point of the corrected article. This formal update serves as a necessary step in the ongoing process of scientific self-correction and documentation.
Frequently Asked Questions
The researchers used Cryo-EM to determine the structure of this channel, which mediates the uptake of calcium ions into the mitochondria. This specific uniporter complex provides the physical pathway for ion translocation across the inner mitochondrial membrane as described in the corrected structural report.
The authors replaced reference 15 and renumbered the sequence of references from 32 to 50 in the online version. These numerical adjustments ensure that the citations in the text correctly correspond to the final bibliography without altering the primary data regarding the mitochondrial calcium uniporter structure.
The renumbering was required to maintain a sequential and accurate citation list after the replacement of reference 15. This process ensures that readers can correctly identify the previous studies and datasets that support the structural analysis of the fungal mitochondrial calcium uniporter within the digital manuscript.
This correction is strictly confined to the bibliographic references and does not modify the experimental results or the high-resolution Cryo-EM structure itself. The authors flag that the renumbering of references 32 to 50 is a clerical update to the online version rather than a scientific revision.
The study's authors propose that the replacement of reference 15 and the renumbering of references 32 to 50 maintain the accuracy of the scholarly record. They conclude that these updates do not change the fundamental structural insights or the mechanistic conclusions drawn from the Cryo-EM data.
More Related Videos
Related Concept Videos
Milgram's Obedience to Authority
Distance Corrections
Animal Mitochondrial Genetics
Power Factor Correction
Interaction of EM Radiation with Matter: Spectroscopy
Fungal Group Zygomycota

