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Updated: Feb 6, 2026
09:38
Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
Published on: August 11, 2017
9.2K
Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?
Gonzalo Recondo1, Francesco Facchinetti2, Ken A Olaussen1
1INSERM U981, Gustave Roussy Cancer Campus, Université Paris Saclay, Villejuif, France.
Nature Reviews. Clinical Oncology
|August 16, 2018
Summary
For advanced non-small cell lung cancer (NSCLC) with ALK or EGFR mutations, next-generation tyrosine kinase inhibitors (TKIs) show promise as a first-line treatment over traditional sequential therapy. This review examines evidence for both approaches in EGFR-driven or ALK-driven NSCLC.
Area of Science:
- Oncology
- Genetics
- Pharmacology
Background:
- The standard treatment for advanced non-small cell lung cancer (NSCLC) with ALK rearrangements or EGFR mutations involves sequential tyrosine kinase inhibitors (TKIs).
- This traditional approach administers first-generation TKIs, followed by next-generation TKIs or chemotherapy upon disease progression.
Purpose of the Study:
- To review and compare the evidence for sequential TKI therapy versus frontline next-generation TKIs in advanced NSCLC.
- To discuss the suitability of these strategies for patients with EGFR-driven or ALK-driven NSCLC.
Main Methods:
- Review of preclinical and clinical evidence.
- Analysis of treatment strategies for ALK-rearranged and EGFR-mutated NSCLC.
Main Results:
- Next-generation TKIs used as first-line therapy demonstrate improved progression-free survival and intracranial disease control.
- First-line next-generation TKIs generally exhibit a favorable toxicity profile compared to sequential approaches.
Conclusions:
- Frontline use of next-generation TKIs presents a viable alternative to traditional sequential treatment for advanced NSCLC.
- The choice of strategy should be tailored to individual patient profiles in EGFR-driven or ALK-driven NSCLC.
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