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Updated: Feb 6, 2026

Zika Virus Specific Diagnostic Epitope Discovery
Published on: December 12, 2017
Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins
Prasanna Marsakatla1, Sujai Suneetha1, Joshua Lee2
1CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad -500029, Telangana, India.
Abstract:
Massive peptide sharing between the Zika virus polyprotein and host tissue proteins could elicit significant host-pathogen interactions and cross-reactions leading to autoimmune diseases. This study found similarities in the Zika V proteins and human nerve tissue proteins. 63 human nerve proteins were screened for similarities with the Zika V of which Neuromodulin, Nestin, Galanin, Bombesin, Calcium-binding protein were found to have similarities to the Zika V poly protein C at different sequence regions. These sequence similarities could be significant in regulating pathogenic interactions/autoimmunity, as Polyprotein C is known to be a virulent factor.
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