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microRNA-1297 involves in the progression of oral squamous cell carcinoma through PTEN

Limin Liang1, Lin Feng1, Bo Wei1

  • 1General Hospital of the People's Liberation Army of China, Beijing 100000, PR China.

Saudi Journal of Biological Sciences
|August 16, 2018
PubMed
Abstract

Insights

MicroRNA-1297 (miRNA-1297) is repressed in oral squamous cell carcinoma (OSCC), inhibiting tumor growth by targeting PTEN. This suggests miRNA-1297 as a potential therapeutic target for OSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Oral squamous cell carcinoma (OSCC) pathogenesis remains unclear.
  • Investigating the role of novel microRNAs (miRNAs) in OSCC development is crucial.

Purpose of the Study:

  • To elucidate the biological function of a newly identified miRNA in OSCC.
  • To explore the relationship between miR-1297 and OSCC progression.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) for miRNA and gene expression profiling.
  • Cell proliferation assays (CCK-8, colony formation) and Western blotting for protein analysis.
  • Statistical analysis using SPSS.

Main Results:

  • MiR-1297 was found to be downregulated in OSCC tissues.
  • Overexpression of miR-1297 suppressed OSCC cell proliferation, while its suppression promoted it.
  • PTEN silencing mimicked the effect of miR-1297 overexpression on OSCC cell growth, indicating PTEN activation in OSCC.

Conclusions:

  • MiRNA and gene expression alterations are frequent in OSCC.
  • MiR-1297 may promote OSCC tumor progression via PTEN regulation.
  • MiR-1297 presents a potential therapeutic target for OSCC.
Keywords:
Cell proliferationMiR-1297PTEN

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