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Updated: Feb 6, 2026

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
Cancer nanomedicine: from PDGF targeted drug delivery
Chandrababu Rejeeth1, Raju Vivek1, Varukattu NipunBabu2
1Department of Biomedical Engineering , MED-X Research Institute , Shanghai Jiao Tong University , Shanghai 200030 , People's Republic of China . Email: crejee@gmail.com ; Email: crejee@sjtu.edu.cn ;
Abstract:
An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin (cis-DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future.
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