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Related Concept Videos

Angle of Twist: Problem Solving01:13

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An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the torque...
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Angle of Twist - Elastic Range01:13

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Consider a cylindrical shaft with a length denoted by L and a consistent cross-sectional radius referred to as r. This shaft undergoes a torque at the free end. The highest shearing strain within the shaft is directly proportional to the twist angle and the radial distance from the shaft axis. When the shaft behaves elastically, this shearing strain can be articulated using variables such as the applied torque, radial distance, the polar moment of inertia, and the modulus of rigidity. By...
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Molecules and Compounds02:38

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What is Gene Expression?01:42

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Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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Related Experiment Video

Updated: Feb 6, 2026

Magnetic Tweezers for the Measurement of Twist and Torque
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Targeting Twist expression with small molecules.

Haixiang Pei1, Yunqi Li1, Mingyao Liu1

  • 1Shanghai Key Laboratory of Regulatory Biology , The Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , Shanghai , 200241 , China . Email: yhchen@bio.ecnu.edu.cn ; ; Tel: +86 21 2420 6647.

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Summary
This summary is machine-generated.

Twist transcription factors regulate cell migration and are crucial in embryonic development and cancer. Targeting Twist expression with small molecules offers a promising therapeutic strategy for various cancers.

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • Twist transcription factors (Twist-1 and Twist-2) are vital for embryonic development, regulating epithelial-mesenchymal transition (EMT) and cell migration.
  • These factors are typically undetectable in healthy adult tissues but are frequently overexpressed in various human cancers, including breast, prostate, liver, and melanoma.
  • Overexpression of Twist is linked to increased cancer aggression, invasion, and metastasis.

Purpose of the Study:

  • To provide an overview of the role of Twist transcription factors in cancer development.
  • To highlight small molecules that target Twist expression.
  • To discuss the biological characteristics of Twist that make it a potential therapeutic target.

Main Methods:

  • Literature review of studies on Twist transcription factors in cancer.
  • Analysis of the role of Twist in epithelial-mesenchymal transition (EMT) and cancer progression.
  • Identification and discussion of small molecules targeting Twist expression.

Main Results:

  • Twist acts as a key inducer of EMT, promoting cancer cell aggression, invasion, and metastasis.
  • Several small molecules have been investigated for their ability to modulate Twist expression and its downstream effects.
  • The biological functions of Twist present it as a significant target for novel cancer therapies.

Conclusions:

  • Twist transcription factors play a critical role in cancer development and progression.
  • Targeting Twist with small molecules represents a viable strategy for cancer treatment.
  • Further research into Twist-targeting therapies holds promise for improving cancer patient outcomes.