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Updated: Feb 6, 2026

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
Published on: June 8, 2016
Light-responsive CO2 bubble-generating polymeric micelles for tumor cell ablation
Yifan Zhang1, Yuncai Guan1, Sizhan Ge1
1State Key Laboratory of Pharmaceutical Biotechnology , Medical School of Nanjing University , Nanjing 210093 , China . Email: wuj@nju.edu.cn ;
Abstract:
We report a novel UV-responsive polymeric micelle system based on coumarin ester for tumor treatment. The micelle itself can generate CO2 under UV exposure owing to the photolysis of (7-diethylaminocoumarin-4-yl)methyl (DEACM). Without loading any drugs, the micelle causes significant cell death under 8 s UV irradiation in vitro. This is the first time to use light to decompose the nano-carrier itself into CO2 bubbles for tumor cell ablation.
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