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Updated: Feb 6, 2026

Author Spotlight: Advancing Mycobacterial Biofilm Protocols for Enhanced Bacterial Metabolism Research
Published on: July 12, 2024
Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c
M A Dallaston1, S Rajan1, J Chekaiban1
1Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia . Email: r.davis@griffith.edu.au ;
Abstract:
The soluble mycobacterial carbonic anhydrases Rv3588c and Rv1284 belong to a different class of carbonic anhydrases than those found in humans, making them attractive drug targets by using the inherent differences in the folds of the different classes. By screening a natural product library, we identified naphthoquinone derivatives as a novel non-classical inhibitor scaffold of mycobacterial carbonic anhydrases that lack the sulfonamide/sulfamate group and thus did not affect human carbonic anhydrase II.
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