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Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps
Published on: August 18, 2012
Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical
Loredana Maiuolo1, Giordana Feriotto2, Vincenzo Algieri1
1Dipartimento di Chimica e Tecnologie Chimiche , Università della Calabria , Via P. Bucci, cubo 12C , 87036 Rende (CS) , Italy . Email: maiuolo@unical.it ;
Abstract:
A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.
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