Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

376
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
376
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

835
Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
835
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

1.0K
Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.7K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K
Characteristics of Practical Op Amps01:16

Characteristics of Practical Op Amps

870
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
870

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multi-omic approach reveals iron availability influences cell fate fidelity.

npj metabolic health and disease·2026
Same author

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.

Cell·2025
Same author

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells.

ACS chemical biology·2025
Same author

Emerging opportunities in the rewiring of biology through proximity inducing small molecules.

RSC medicinal chemistry·2025
Same author

Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma.

Nature communications·2025
Same author

Relative importance of the anti-apoptotic versus apoptosis-unrelated functions of MCL-1 in vivo.

Science (New York, N.Y.)·2025
Same journal

Selective <i>in vitro</i> anti-cancer activity of non-alkylating minor groove binders.

MedChemComm·2020
Same journal

Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia.

MedChemComm·2020
Same journal

A focused structure-activity relationship study of psoralen-based immunoproteasome inhibitors.

MedChemComm·2020
Same journal

Characterization of the genomically encoded fosfomycin resistance enzyme from <i>Mycobacterium abscessus</i>.

MedChemComm·2020
Same journal

Indole compounds with <i>N</i>-ethyl morpholine moieties as CB2 receptor agonists for anti-inflammatory management of pain: synthesis and biological evaluation.

MedChemComm·2020
Same journal

The cytotoxic potential of cationic triangulenes against tumour cells.

MedChemComm·2020
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Practical Methodology of Cognitive Tasks Within a Navigational Assessment
05:19

Practical Methodology of Cognitive Tasks Within a Navigational Assessment

Published on: June 1, 2015

14.0K

Approaches to target tractability assessment - a practical perspective.

Kristin K Brown1, Michael M Hann2, Ami S Lakdawala3

  • 1Computational and Modelling Sciences , Platform Technology and Sciences , GlaxoSmithKline , 1250 S. Collegeville Road , Collegeville , Pennsylvania 19426 , USA.

Medchemcomm
|August 16, 2018
PubMed
Summary
This summary is machine-generated.

Assessing drug target tractability early in discovery is crucial. This review covers in silico and experimental methods for evaluating target suitability for small molecules and antibodies.

More Related Videos

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective
13:57

Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective

Published on: July 1, 2015

13.2K

Related Experiment Videos

Last Updated: Feb 6, 2026

Practical Methodology of Cognitive Tasks Within a Navigational Assessment
05:19

Practical Methodology of Cognitive Tasks Within a Navigational Assessment

Published on: June 1, 2015

14.0K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective
13:57

Assessing the Multiple Dimensions of Engagement to Characterize Learning: A Neurophysiological Perspective

Published on: July 1, 2015

13.2K

Area of Science:

  • Drug discovery and development
  • Pharmacology
  • Biotechnology

Background:

  • Selecting viable drug targets is critical for successful drug discovery.
  • Evaluating target suitability for different therapeutic modalities (e.g., small molecules, antibodies) is increasingly important.
  • Early assessment of target tractability aids in prioritizing the most promising candidates.

Purpose of the Study:

  • To review the concept of target tractability in drug discovery.
  • To discuss various aspects of tractability assessment.
  • To explore the application of in silico and experimental methods for evaluating target suitability.

Main Methods:

  • Literature review and perspective synthesis.
  • Discussion of in silico approaches for predicting target tractability.
  • Overview of experimental methods used in tractability assessment.

Main Results:

  • Tractability is a multifaceted concept influenced by target properties.
  • Both computational and experimental strategies can provide insights into target tractability.
  • The integration of diverse assessment methods enhances target selection.

Conclusions:

  • Early and comprehensive assessment of target tractability is essential for efficient drug discovery.
  • Utilizing a combination of in silico and experimental approaches optimizes the selection of druggable targets.
  • Sharing experiences in tractability assessment can guide future drug development strategies.