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Updated: Feb 6, 2026

Practical Methodology of Cognitive Tasks Within a Navigational Assessment
Published on: June 1, 2015
Approaches to target tractability assessment - a practical perspective
Kristin K Brown1, Michael M Hann2, Ami S Lakdawala3
1Computational and Modelling Sciences , Platform Technology and Sciences , GlaxoSmithKline , 1250 S. Collegeville Road , Collegeville , Pennsylvania 19426 , USA.
Abstract:
The assessment of the suitability of novel targets to intervention by different modalities, e.g. small molecules or antibodies, is increasingly seen as important in helping to select the most progressable targets at the outset of a drug discovery project. This perspective considers differing aspects of tractability and how it can be assessed using in silico and experimental approaches. We also share some of our experiences in using these approaches.
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