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Updated: Feb 6, 2026

An Experimental Protocol for Studying Mineral Effects on Organic Hydrothermal Transformations
Published on: August 8, 2018
Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from
Lin Tang1, Tao Peng1, Gang Wang1
1Beijing Institute of Radiation Medicine , Beijing 100850 , P. R. China . Email: wanglin@bmi.ac.cn ; Email: wanglin07@sina.com ; Tel: +86 010 66932239.
Abstract:
In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents. Some of the compounds considerably protected HUVECs against 60Co γ-irradiation, accompanied by the absence of cytotoxicity. Compared to Ex-RAD, compound 8n not only exhibited a significant protective effect on cell survival and radiation-induced DNA damage, but also remarkably enhanced the survival (100%) of mice in 30 days after being exposed to irradiation. The results suggested that some target compounds are valuable for further research as promising radioprotectors.
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