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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Related Experiment Video

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Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
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Adaptive Laboratory Evolution for Enhanced Carotenoid Production in Microalgae.

Yixi Su1, Zhiqian Yi1, Snædís Huld Björnsdóttir1

  • 1Center for Systems Biology and Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, School of Engineering and Natural Sciences, University of Iceland, Reykjavík, Iceland.

Methods in Molecular Biology (Clifton, N.J.)
|August 16, 2018
PubMed
Summary

Adaptive laboratory evolution (ALE) improves microalgal strains for industrial pigment production. This method enhances carotenoid yield, making natural pigments more competitive by reducing costs.

Keywords:
Abiotic stressAdaptive laboratory evolution (ALE)CarotenoidsDunaliella salinaGreen algaeResponse surface methodology (RSM)

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Area of Science:

  • Biotechnology
  • Microalgal cultivation
  • Metabolic engineering

Background:

  • Industrial production of natural pigments requires cost-effective algal strains.
  • Current microalgal strains need improvement to increase valuable metabolite productivity.
  • Adaptive laboratory evolution (ALE) is a proven method for strain improvement in microorganisms.

Purpose of the Study:

  • To describe a strategy for improving microalgal strains using ALE.
  • To enhance carotenoid yield from microalgae for industrial applications.
  • To reduce the overall production cost of natural pigments.

Main Methods:

  • Implementing a stepwise adaptive evolution strategy.
  • Utilizing ALE to select for microalgal strains with higher carotenoid production.
  • Focusing on improving productivity of valuable metabolites in microalgae.

Main Results:

  • The described ALE strategy effectively enhances carotenoid yield.
  • Improved microalgal strains show increased productivity of target metabolites.
  • Potential for cost reduction in natural pigment production.

Conclusions:

  • ALE is a viable approach for microalgal strain improvement in biotechnology.
  • Enhanced carotenoid production through ALE contributes to competitive natural pigment pricing.
  • This strategy supports the industrial application of microalgal biotechnology.