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Related Experiment Video

Updated: Feb 6, 2026

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

Nanoscale Functionalized Particles with Rotation-Controlled Capture in Shear Flow.

Molly K Shave, Surachate Kalasin, Eric Ying

ACS Applied Materials & Interfaces

|August 16, 2018

Summary

Engineered microparticles with sparse adhesive patches capture flowing particles. Capture rates depend on particle rotation, offering insights into cell detection and targeted drug delivery.

Keywords:

colloid deposition flow flow vorticity hydrodynamic microparticle capture patchy particles shear surface heterogeneity

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Last Updated: Feb 6, 2026

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

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Published on: August 6, 2021

Area of Science:

Fluid dynamics
Surface chemistry
Biotechnology

Background:

Adhesive particle capture is crucial in natural and technological processes.
Understanding capture mechanisms is key for applications like cell separation and drug delivery.

Purpose of the Study:

To introduce engineered microparticles with controlled adhesive properties.
To investigate how particle rotation and surface functionalization affect capture rates in shear flow.

Main Methods:

Fabrication of sparsely functionalized spherical microparticles.
Utilizing a shear-chamber to study particle capture dynamics.
Comparing capture rates when functionality is on particles versus the chamber wall.

Main Results:

Capture rates are limited by near-surface particle motion, specifically rotation.
Particle rotation continually exposes new surface area, controlling capture.
Functionalizing the chamber wall, instead of particles, led to faster capture due to particle translation.

Conclusions:

Engineered patchy microparticles offer a new tool for studying surface-limited capture.
Findings provide insights into capturing sparse cell surface features and designing targeted delivery systems.