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Updated: Feb 6, 2026
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[Research progress in PRAS40]
Gang Chen1, Gangcai Zhu1, Xin Zhang1
1Department of Otorhinolaryngology Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Summary
Prolin-rich Akt substrate of 40 kD (PRAS40) is a key protein regulated by phosphorylation. PRAS40 impacts cell growth, senescence, and apoptosis through various signaling pathways like mTORC1 and Akt.
Area of Science:
- Molecular Biology
- Cell Signaling
Background:
- Prolin-rich Akt substrate of 40 kD (PRAS40) was identified in 2003 as a 14-3-3 protein partner and Akt kinase substrate.
- PRAS40 activation primarily occurs through phosphorylation at distinct sites.
Purpose of the Study:
- To elucidate the role of PRAS40 in cellular processes.
- To understand PRAS40's involvement in key signaling pathways.
Main Methods:
- Review of existing literature on PRAS40.
- Analysis of PRAS40's phosphorylation and its downstream effects.
Main Results:
- PRAS40 is implicated in regulating cell proliferation, senescence, autophagy, and apoptosis.
- PRAS40 interacts with signaling pathways including mTORC1, Akt, NF-κB, and RPL11.
Conclusions:
- PRAS40 plays a significant role in cellular regulation.
- Phosphorylation of PRAS40 is critical for its function in diverse biological processes.
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