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Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Alexandre Slater1, Gina Perrella1,2, Marie-Blanche Onselaer1

  • 1a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

Platelets
|August 16, 2018
PubMed
Summary

Conflicting findings on fibrin binding to platelet receptor GPVI (glycoprotein VI) stem from a lack of structural understanding and non-standardized reagents. Addressing these issues is key to reconciling results on GPVI signaling.

Keywords:
CollagenGPVIfibrin(ogen)platelets

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