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Updated: Feb 6, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
Published on: March 10, 2020
Emerging function and potential diagnostic value of circular RNAs in cancer
Xianglun Cui1, Jianxun Wang2, Zongjun Guo3
1Department of Inspection, The medical faculty of Qingdao University, Qingdao, 266003, China.
Abstract:
As a novel class of endogenous RNAs, circRNAs, have a covalently closed continuous loop, with neither a 5'to 3'polarity, nor a polyadenylated tail. Numerous circRNAs have been characterized by abundance, stabilization, conservation, and exhibit tissue/developmental stage-specific expression. Furthermore, circRNAs play vital roles in tumorigenesis and metastasis, such as functioning as a ceRNA or miRNA sponge, interacting with protein and encoding protein. Increasing evidence has revealed that it potentially serves as a required novel biomarker for cancer diagnosis. This review summarized the latest research on circRNAs, including its classification and biogenesis, mechanism and functions, as well as circRNAs in different cancers, as a potential biomarker.
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