Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diffusion01:12

Diffusion

219.9K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
219.9K
Diffusion01:21

Diffusion

6.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.4K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.6K
5.6K
Facilitated Diffusion01:16

Facilitated Diffusion

1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
What is Gene Expression?01:42

What is Gene Expression?

196.9K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The functional roles and therapeutic potential of protein palmitoylation in hepatocellular carcinoma.

Discover oncology·2026
Same author

Tumor metabolic heterogeneity based on <sup>18</sup>F-FDG PET/CT is a predictor of outcome in diffuse large B-cell lymphoma.

BMC cancer·2025
Same author

Mechanism and role of ferroptosis in the development of gastric cancer.

Clinical and experimental medicine·2025
Same author

The Research on the Esterification Deacidification of Vacuum Gas Oil by FeZn Bimetal-Organic Frameworks Catalysts.

Materials (Basel, Switzerland)·2025
Same author

Incremental Prognostic Value of Perivascular Fat Attenuation Index in Patients with Diabetes with Coronary Artery Disease.

Radiology. Cardiothoracic imaging·2025
Same author

[Analysis of <i>SRSF2</i> Gene Mutation in Patients with Chronic Myelomonocytic Leukemia].

Zhongguo shi yan xue ye xue za zhi·2025

Related Experiment Video

Updated: Feb 6, 2026

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells
09:58

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

8.1K

[Expression and Function of miR-181b in Diffuse Large B Cell Lymphoma].

Bai He1, Dan-Xia Zhu2, Hong-Ying Chao3

  • 1Department of Hematology,Changzhou First People's Hospital,Changzhou 213000,Jiangsu Province,China.E-mail: hebai_25858@163.com.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|August 17, 2018
PubMed
Summary

MicroRNA-181b (miR-181b) is highly expressed in diffuse large B cell lymphoma (DLBCL) and correlates with advanced stages and poor prognosis. Lower miR-181b levels indicate better survival rates in DLBCL patients.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.9K

Related Experiment Videos

Last Updated: Feb 6, 2026

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells
09:58

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

8.1K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.9K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Diffuse large B cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • MicroRNAs play crucial roles in lymphomagenesis and cancer progression.
  • The specific role of miR-181b in DLBCL requires further elucidation.

Purpose of the Study:

  • To investigate the expression levels of miR-181b in DLBCL tissues.
  • To analyze the correlation between miR-181b expression and clinical features of DLBCL.
  • To evaluate the prognostic significance of miR-181b in DLBCL patients.

Main Methods:

  • Quantitative analysis of miR-181b expression in 124 DLBCL patients and 64 healthy controls.
  • Comparison of miR-181b levels based on clinical staging (Ann Arbor) and International Prognostic Index (IPI) scores.
  • Survival analysis correlating miR-181b expression levels with patient outcomes.

Main Results:

  • miR-181b expression was significantly elevated in DLBCL tissues compared to healthy controls (P<0.05).
  • Higher miR-181b levels correlated positively with advanced Ann Arbor stage and higher IPI scores (P<0.05).
  • Patients with low miR-181b expression exhibited a significantly higher 5-year survival rate than those with high expression (P<0.05).

Conclusions:

  • miR-181b expression differs significantly in DLBCL patients based on clinical stage and prognosis.
  • miR-181b may serve as a valuable diagnostic and prognostic biomarker for DLBCL.
  • Further research into miR-181b's functional role in DLBCL pathogenesis is warranted.