Related Experiment Video
Updated: Feb 6, 2026
10:25
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
Published on: March 19, 2016
10.0K
[Analysis of Relationship between Coagulation Function and Blood Transfusion in Patients with Emergency Rescue]
Xin-Fang Zhu1, Yu-Bo Wu1, Li-Hui Yang1
1Department of Blood Transfusion, The Affiliated Huashan Hospital of Fudan University, Shanghai 200041, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|August 17, 2018
Summary
Preoperative coagulation function impacts blood product transfusion volumes during surgery. Emergency O type blood and ABO-matched transfusions are equally safe and effective for rescue.
Area of Science:
- Transfusion Medicine
- Surgical Hemostasis
- Coagulation Physiology
Background:
- Assessing preoperative coagulation status is crucial for managing intraoperative blood loss.
- Emergency transfusion protocols require careful consideration of blood product volumes and patient coagulation.
- Understanding the relationship between transfusion volume and coagulation parameters is vital for patient safety.
Purpose of the Study:
- To investigate the impact of preoperative coagulation function on blood product transfusion volumes during emergency rescue transfusions.
- To analyze the relationship between the volume of blood products transfused and changes in coagulation function.
- To evaluate the safety and efficacy of emergency O type blood and ABO-matched blood transfusions.
Main Methods:
- Retrospective analysis of 218 surgical cases with >1600 ml transfusion from Aug 2015 to Dec 2016.
- Patients categorized into normal (Group A) and abnormal (Group B) coagulation groups, plus emergency O type transfusion group (Group C).
- Analysis of transfusion volumes (RBC, VIFP, FFP, C, P) and coagulation parameters (PT, APTT, FIB, INR), alongside post-transfusion Hb, IBiL, DAT, and antibody screening.
Main Results:
- Group C showed significantly higher transfusion volumes of RBC, FFP, C, and Platelets compared to Groups A and B.
- Coagulation parameters (PT, APTT, FIB, INR) in Groups B and C differed significantly and correlated with transfusion volumes.
- Post-transfusion hemoglobin levels remained stable, and no new irregular antibodies were detected, indicating transfusion safety.
Conclusions:
- Preoperative coagulation function is a key determinant of intraoperative blood product transfusion requirements.
- Emergency O type blood transfusions offer comparable efficacy and safety to ABO-matched transfusions.
- Coagulation status evaluation serves as a basis for managing bleeding and guiding transfusion strategies.
More Related Videos
09:58Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
3.1K
09:38A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
14.4K
Related Concept Videos
01:15Blood Transfusion
2.4K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.4K
02:45Blood Transfusion and Agglutination
14.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.8K
01:06Coagulation
1.4K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.4K
01:09Coagulation
10.6K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
10.6K
02:12Relationship Formation
46.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.2K
01:27Emerging Adulthood
700
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
700